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Avascular necrosis
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Everything about Aseptic Bone Necrosis totally explained

Avascular necrosis is a disease resulting from the temporary or permanent loss of the blood supply to the bones. Without blood, the bone tissue dies and causes the bone to collapse., excessive steroid use, post trauma , caisson disease (decompression sickness), vascular compression, hypertension, vasculitis, thrombosis, damage from radiation, bisphosphonates (particularly the mandible) and sickle cell anaemia. In some cases it's idiopathic (no cause is found). Rheumatoid arthritis and lupus are also common causes of AVN.

Presentation

While it can, by definition, affect any bone, and half of cases show multiple sites of damage, this disease primarily affects the joints at the shoulder, knee, and hip.
   Although it can happen in any bone, avascular necrosis most commonly affects the ends (epiphysis) of long bones such as the femur, the bone extending from the knee joint to the hip joint. Other common sites include the humerus (the bone of the upper arm), knees , shoulders, ankles and the jaw. The disease may affect just one bone, more than one bone at the same time, or more than one bone at different times. Avascular necrosis usually affects people between 30 and 50 years of age; about 10,000 to 20,000 people develop avascular necrosis of the head of the femur in the US each year. When it occurs in children at the femoral head, it's known as Legg-Calvé-Perthes syndrome.

Diagnosis

Orthopaedic doctors most often diagnose the disease except when it affects the jaws, when it's usually diagnosed and treated by dental and maxillofacial surgeons.
   Because early x-rays are usually normal in the early stage of the disease, bone scintigraphy and MRI are the diagnostic modalities of choice since both can detect minimal changes at early stages of the disease.

Treatment

Avascular necrosis is especially common in the hip joint. A variety of methods are now used to treat avascular necrosis. The bone is broken down by osteoclasts and rebuilt by osteoblasts.
   Other treatments include Core Decompression, where internal bone pressure is relieved by drilling a hole into the bone, and living bone chip and electrical device to stimulate new vascular growth are implanted; and the Free Vascular Fibular Graft (FVFG), in which a portion of the fibula, along with its blood supply, is removed and transplanted into the femoral head.
   The amount of disability that results from avascular necrosis depends on what part of the bone is affected, how large an area is involved, and how effectively the bone rebuilds itself. The process of bone rebuilding takes place after an injury as well as during normal growth Other sports stars with this condition are former NFL running back Garrison Hearst, cyclist Floyd Landis, NFL quarterback Brett Favre, professional wrestler "Superstar" Billy Graham, wrestler Joe Heat, NBA player Jorge Garbajosa and the drummer/singer of the band, The Monkees, Micky Dolenz.
   

Further Information

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